Fabry disease is a rare genetic disorder caused by the buildup of a fat-like substance called globotriaosylceramide due to a deficiency of the enzyme alpha-galactosidase A. This buildup affects various parts of the body, including the heart, kidneys, nervous system, and skin. In terms of foot involvement, Fabry disease can cause burning pain, tingling, and numbness, primarily due to nerve damage, or neuropathy in the feet. This discomfort often becomes worse by physical activity or heat. Diagnosis involves blood tests to measure enzyme levels, genetic testing to confirm mutations, and tissue biopsies to detect GL-3 accumulation. Early diagnosis is imperative as symptoms can progress. If you have foot discomfort or neuropathy, it is strongly suggested that you schedule an appointment with a podiatrist for a proper diagnosis and treatment to help relieve symptoms.
When dealing with systemic disease of the feet, it is extremely important to check the affected areas routinely so that any additional problems are caught quickly. If you have any concerns about your feet and ankles contact Mark Poplawski, DPM from Jersey Shore Podiatry, LLC. Our doctor will assist you with all of your podiatric needs.
Systemic Diseases of the Feet
Systemic diseases affect the whole body, and symptoms usually are displayed in the feet. This condition can make a patient’s ability to walk unbearable. Systemic diseases include gout, diabetes mellitus, neurological disorders, and arthritis.
Gout – is caused by an excess of uric acid in the body. Common symptoms include pain, inflammation, and redness at the metatarsal/phalangeal joint of the base big toe. Gout can be treated by NSAIDs to relieve pain and inflammation, and other drugs that lower the acid levels in the body.
Diabetes mellitus – is an increase in the level of blood sugar that the body cannot counteract with its own insulin. Failure to produce enough insulin is a factor in Diabetes.
Diabetes of the Feet
Diabetic Neuropathy – may lead to damaged nerves and affect the feet through numbness and loss of sensation.
Peripheral Vascular Disease – can restrict the blood flow to the feet, and often times lead to amputation of the feet.
If you have any questions please feel free to contact our office located in Toms River, NJ . We offer the newest diagnostic and treatment technologies for all your foot and ankle needs.
